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Job Name:
Proteome profiling of HeLa cells with DTT-induced ER stress
Current Gene List:
Background List:
Submitted Network
Note: Only the top 1000 records are shown here
| Category | Term | Genes | Count | % | P-value | Benjamini |
|---|---|---|---|---|---|---|
| KEGG_PATHWAY | hsa05200:Pathways in cancer | 173 | 15.8 | 4.1e-52 | 1.0e-49 | |
| KEGG_PATHWAY | hsa04151:PI3K-Akt signaling pathway | 140 | 12.8 | 3.5e-37 | 4.2e-35 | |
| KEGG_PATHWAY | hsa04915:Estrogen signaling pathway | 68 | 6.2 | 1.0e-36 | 8.1e-35 | |
| KEGG_PATHWAY | hsa04015:Rap1 signaling pathway | 103 | 9.4 | 4.3e-36 | 2.6e-34 | |
| KEGG_PATHWAY | hsa04012:ErbB signaling pathway | 63 | 5.8 | 2.0e-35 | 9.5e-34 | |
| KEGG_PATHWAY | hsa05205:Proteoglycans in cancer | 99 | 9.0 | 3.6e-35 | 1.5e-33 | |
| KEGG_PATHWAY | hsa04510:Focal adhesion | 101 | 9.2 | 3.8e-35 | 1.3e-33 | |
| KEGG_PATHWAY | hsa04917:Prolactin signaling pathway | 54 | 4.9 | 8.6e-32 | 2.6e-30 | |
| KEGG_PATHWAY | hsa05169:Epstein-Barr virus infection | 88 | 8.0 | 3.4e-29 | 9.1e-28 | |
| KEGG_PATHWAY | hsa04664:Fc epsilon RI signaling pathway | 50 | 4.6 | 8.8e-29 | 2.1e-27 | |
| KEGG_PATHWAY | hsa05161:Hepatitis B | 76 | 6.9 | 2.1e-28 | 4.7e-27 | |
| KEGG_PATHWAY | hsa05203:Viral carcinogenesis | 87 | 7.9 | 5.6e-28 | 1.1e-26 | |
| KEGG_PATHWAY | hsa05220:Chronic myeloid leukemia | 51 | 4.7 | 1.4e-27 | 2.7e-26 | |
| KEGG_PATHWAY | hsa04068:FoxO signaling pathway | 71 | 6.5 | 1.8e-27 | 3.1e-26 | |
| KEGG_PATHWAY | hsa05214:Glioma | 47 | 4.3 | 4.6e-27 | 7.5e-26 | |
| KEGG_PATHWAY | hsa04540:Gap junction | 55 | 5.0 | 5.1e-27 | 7.6e-26 | |
| KEGG_PATHWAY | hsa04912:GnRH signaling pathway | 55 | 5.0 | 1.6e-25 | 2.2e-24 | |
| KEGG_PATHWAY | hsa04722:Neurotrophin signaling pathway | 64 | 5.8 | 2.3e-25 | 3.1e-24 | |
| KEGG_PATHWAY | hsa04660:T cell receptor signaling pathway | 59 | 5.4 | 3.6e-25 | 4.6e-24 | |
| KEGG_PATHWAY | hsa04062:Chemokine signaling pathway | 82 | 7.5 | 5.2e-25 | 6.3e-24 | |
| KEGG_PATHWAY | hsa04114:Oocyte meiosis | 59 | 5.4 | 1.5e-24 | 1.7e-23 | |
| KEGG_PATHWAY | hsa04914:Progesterone-mediated oocyte maturation | 53 | 4.8 | 1.5e-24 | 1.7e-23 | |
| KEGG_PATHWAY | hsa04750:Inflammatory mediator regulation of TRP channels | 55 | 5.0 | 7.5e-24 | 7.9e-23 | |
| KEGG_PATHWAY | hsa04910:Insulin signaling pathway | 66 | 6.0 | 1.6e-22 | 1.7e-21 | |
| KEGG_PATHWAY | hsa04921:Oxytocin signaling pathway | 71 | 6.5 | 1.8e-22 | 1.7e-21 | |
| KEGG_PATHWAY | hsa04370:VEGF signaling pathway | 42 | 3.8 | 1.9e-22 | 1.8e-21 | |
| KEGG_PATHWAY | hsa04014:Ras signaling pathway | 88 | 8.0 | 4.8e-22 | 4.3e-21 | |
| KEGG_PATHWAY | hsa05215:Prostate cancer | 51 | 4.7 | 6.6e-22 | 5.7e-21 | |
| KEGG_PATHWAY | hsa05166:HTLV-I infection | 95 | 8.7 | 1.9e-21 | 1.5e-20 | |
| KEGG_PATHWAY | hsa04611:Platelet activation | 62 | 5.7 | 6.4e-21 | 5.2e-20 | |
| KEGG_PATHWAY | hsa05206:MicroRNAs in cancer | 65 | 5.9 | 1.2e-20 | 9.4e-20 | |
| KEGG_PATHWAY | hsa04066:HIF-1 signaling pathway | 52 | 4.7 | 3.3e-20 | 2.5e-19 | |
| KEGG_PATHWAY | hsa04071:Sphingolipid signaling pathway | 56 | 5.1 | 4.9e-20 | 3.6e-19 | |
| KEGG_PATHWAY | hsa05212:Pancreatic cancer | 41 | 3.7 | 5.2e-19 | 3.7e-18 | |
| KEGG_PATHWAY | hsa04662:B cell receptor signaling pathway | 42 | 3.8 | 5.5e-19 | 3.8e-18 | |
| KEGG_PATHWAY | hsa04024:cAMP signaling pathway | 76 | 6.9 | 1.8e-18 | 1.2e-17 | |
| KEGG_PATHWAY | hsa04725:Cholinergic synapse | 54 | 4.9 | 2.0e-18 | 1.3e-17 | |
| KEGG_PATHWAY | hsa05210:Colorectal cancer | 39 | 3.6 | 4.9e-18 | 3.1e-17 | |
| KEGG_PATHWAY | hsa04666:Fc gamma R-mediated phagocytosis | 45 | 4.1 | 7.3e-18 | 4.5e-17 | |
| KEGG_PATHWAY | hsa04520:Adherens junction | 40 | 3.7 | 1.1e-17 | 6.6e-17 | |
| KEGG_PATHWAY | hsa04650:Natural killer cell mediated cytotoxicity | 54 | 4.9 | 1.5e-17 | 8.7e-17 | |
| KEGG_PATHWAY | hsa05223:Non-small cell lung cancer | 36 | 3.3 | 1.9e-17 | 1.1e-16 | |
| KEGG_PATHWAY | hsa05221:Acute myeloid leukemia | 36 | 3.3 | 1.9e-17 | 1.1e-16 | |
| KEGG_PATHWAY | hsa05142:Chagas disease (American trypanosomiasis) | 51 | 4.7 | 2.0e-17 | 1.1e-16 | |
| KEGG_PATHWAY | hsa05100:Bacterial invasion of epithelial cells | 41 | 3.7 | 2.1e-17 | 1.2e-16 | |
| KEGG_PATHWAY | hsa05211:Renal cell carcinoma | 38 | 3.5 | 2.2e-17 | 1.2e-16 | |
| KEGG_PATHWAY | hsa04919:Thyroid hormone signaling pathway | 53 | 4.8 | 5.2e-17 | 2.7e-16 | |
| KEGG_PATHWAY | hsa04720:Long-term potentiation | 38 | 3.5 | 1.0e-16 | 5.6e-16 | |
| KEGG_PATHWAY | hsa05231:Choline metabolism in cancer | 46 | 4.2 | 4.6e-16 | 2.2e-15 | |
| KEGG_PATHWAY | hsa04630:Jak-STAT signaling pathway | 60 | 5.5 | 4.7e-16 | 2.2e-15 | |
| KEGG_PATHWAY | hsa04110:Cell cycle | 55 | 5.0 | 5.2e-16 | 2.7e-15 | |
| KEGG_PATHWAY | hsa05213:Endometrial cancer | 33 | 3.0 | 9.4e-16 | 4.2e-15 | |
| KEGG_PATHWAY | hsa05146:Amoebiasis | 49 | 4.5 | 2.2e-15 | 1.0e-14 | |
| KEGG_PATHWAY | hsa04261:Adrenergic signaling in cardiomyocytes | 59 | 5.4 | 3.0e-15 | 1.4e-14 | |
| KEGG_PATHWAY | hsa05164:Influenza A | 64 | 5.8 | 3.8e-15 | 1.7e-14 | |
| KEGG_PATHWAY | hsa04022:cGMP-PKG signaling pathway | 63 | 5.8 | 4.1e-15 | 1.8e-14 | |
| KEGG_PATHWAY | hsa05145:Toxoplasmosis | 50 | 4.6 | 2.3e-14 | 9.8e-14 | |
| KEGG_PATHWAY | hsa05160:Hepatitis C | 54 | 4.9 | 2.7e-14 | 1.2e-13 | |
| KEGG_PATHWAY | hsa05218:Melanoma | 37 | 3.4 | 8.2e-14 | 3.4e-13 | |
| KEGG_PATHWAY | hsa04930:Type II diabetes mellitus | 30 | 2.7 | 8.7e-14 | 3.6e-13 | |
| KEGG_PATHWAY | hsa04010:MAPK signaling pathway | 81 | 7.4 | 9.1e-14 | 3.7e-13 | |
| KEGG_PATHWAY | hsa04931:Insulin resistance | 47 | 4.3 | 1.4e-13 | 5.7e-13 | |
| KEGG_PATHWAY | hsa05222:Small cell lung cancer | 41 | 3.7 | 1.5e-13 | 6.0e-13 | |
| KEGG_PATHWAY | hsa04380:Osteoclast differentiation | 52 | 4.7 | 2.5e-13 | 9.7e-13 | |
| KEGG_PATHWAY | hsa04923:Regulation of lipolysis in adipocytes | 32 | 2.9 | 3.3e-13 | 1.3e-12 | |
| KEGG_PATHWAY | hsa05162:Measles | 52 | 4.7 | 5.2e-13 | 1.9e-12 | |
| KEGG_PATHWAY | hsa04916:Melanogenesis | 43 | 3.9 | 1.3e-12 | 4.6e-12 | |
| KEGG_PATHWAY | hsa05219:Bladder cancer | 26 | 2.4 | 1.6e-12 | 5.6e-12 | |
| KEGG_PATHWAY | hsa04810:Regulation of actin cytoskeleton | 69 | 6.3 | 2.0e-12 | 7.0e-12 | |
| KEGG_PATHWAY | hsa04670:Leukocyte transendothelial migration | 47 | 4.3 | 2.3e-12 | 8.0e-12 | |
| KEGG_PATHWAY | hsa04730:Long-term depression | 31 | 2.8 | 2.5e-12 | 8.8e-12 | |
| KEGG_PATHWAY | hsa04728:Dopaminergic synapse | 49 | 4.5 | 4.6e-12 | 1.6e-11 | |
| KEGG_PATHWAY | hsa04668:TNF signaling pathway | 44 | 4.0 | 9.8e-12 | 3.3e-11 | |
| KEGG_PATHWAY | hsa04713:Circadian entrainment | 40 | 3.7 | 1.2e-11 | 4.0e-11 | |
| KEGG_PATHWAY | hsa05152:Tuberculosis | 58 | 5.3 | 3.3e-11 | 1.1e-10 | |
| KEGG_PATHWAY | hsa05168:Herpes simplex infection | 59 | 5.4 | 4.9e-11 | 1.6e-10 | |
| KEGG_PATHWAY | hsa04310:Wnt signaling pathway | 50 | 4.6 | 5.8e-11 | 1.8e-10 | |
| KEGG_PATHWAY | hsa04932:Non-alcoholic fatty liver disease (NAFLD) | 51 | 4.7 | 9.6e-11 | 3.0e-10 | |
| KEGG_PATHWAY | hsa05131:Shigellosis | 31 | 2.8 | 1.2e-10 | 3.8e-10 | |
| KEGG_PATHWAY | hsa04723:Retrograde endocannabinoid signaling | 39 | 3.6 | 3.8e-10 | 1.2e-9 | |
| KEGG_PATHWAY | hsa04922:Glucagon signaling pathway | 38 | 3.5 | 5.5e-10 | 1.7e-9 | |
| KEGG_PATHWAY | hsa04925:Aldosterone synthesis and secretion | 34 | 3.1 | 7.1e-10 | 2.1e-9 | |
| KEGG_PATHWAY | hsa04620:Toll-like receptor signaling pathway | 40 | 3.7 | 7.5e-10 | 2.2e-9 | |
| KEGG_PATHWAY | hsa04920:Adipocytokine signaling pathway | 31 | 2.8 | 3.0e-9 | 8.6e-9 | |
| KEGG_PATHWAY | hsa04924:Renin secretion | 28 | 2.6 | 3.2e-9 | 9.2e-9 | |
| KEGG_PATHWAY | hsa04960:Aldosterone-regulated sodium reabsorption | 22 | 2.0 | 4.6e-9 | 1.3e-8 | |
| KEGG_PATHWAY | hsa04270:Vascular smooth muscle contraction | 41 | 3.7 | 6.3e-9 | 1.8e-8 | |
| KEGG_PATHWAY | hsa04150:mTOR signaling pathway | 27 | 2.5 | 6.8e-9 | 1.9e-8 | |
| KEGG_PATHWAY | hsa04971:Gastric acid secretion | 30 | 2.7 | 9.4e-9 | 2.6e-8 | |
| KEGG_PATHWAY | hsa05133:Pertussis | 31 | 2.8 | 9.8e-9 | 2.7e-8 | |
| KEGG_PATHWAY | hsa04210:Apoptosis | 28 | 2.6 | 1.2e-8 | 3.3e-8 | |
| KEGG_PATHWAY | hsa04020:Calcium signaling pathway | 54 | 4.9 | 1.3e-8 | 3.4e-8 | |
| KEGG_PATHWAY | hsa05130:Pathogenic Escherichia coli infection | 24 | 2.2 | 2.6e-8 | 6.9e-8 | |
| KEGG_PATHWAY | hsa04550:Signaling pathways regulating pluripotency of stem cells | 45 | 4.1 | 3.3e-8 | 8.6e-8 | |
| KEGG_PATHWAY | hsa04918:Thyroid hormone synthesis | 28 | 2.6 | 4.1e-8 | 1.1e-7 | |
| KEGG_PATHWAY | hsa04152:AMPK signaling pathway | 41 | 3.7 | 5.7e-8 | 1.5e-7 | |
| KEGG_PATHWAY | hsa05132:Salmonella infection | 31 | 2.8 | 1.2e-7 | 2.9e-7 | |
| KEGG_PATHWAY | hsa04911:Insulin secretion | 32 | 2.9 | 1.5e-7 | 3.8e-7 | |
| KEGG_PATHWAY | hsa05143:African trypanosomiasis | 18 | 1.6 | 1.8e-7 | 4.5e-7 | |
| KEGG_PATHWAY | hsa05120:Epithelial cell signaling in Helicobacter pylori infection | 26 | 2.4 | 5.4e-7 | 1.3e-6 | |
| KEGG_PATHWAY | hsa05230:Central carbon metabolism in cancer | 25 | 2.3 | 7.8e-7 | 1.9e-6 | |
| KEGG_PATHWAY | hsa04724:Glutamatergic synapse | 36 | 3.3 | 8.6e-7 | 2.1e-6 | |
| KEGG_PATHWAY | hsa05031:Amphetamine addiction | 25 | 2.3 | 1.1e-6 | 2.6e-6 | |
| KEGG_PATHWAY | hsa04621:NOD-like receptor signaling pathway | 23 | 2.1 | 1.1e-6 | 2.6e-6 | |
| KEGG_PATHWAY | hsa04970:Salivary secretion | 28 | 2.6 | 1.3e-6 | 3.0e-6 | |
| KEGG_PATHWAY | hsa04120:Ubiquitin mediated proteolysis | 40 | 3.7 | 1.8e-6 | 4.1e-6 | |
| KEGG_PATHWAY | hsa05140:Leishmaniasis | 26 | 2.4 | 2.0e-6 | 4.7e-6 | |
| KEGG_PATHWAY | hsa04390:Hippo signaling pathway | 43 | 3.9 | 2.9e-6 | 6.5e-6 | |
| KEGG_PATHWAY | hsa04144:Endocytosis | 59 | 5.4 | 6.6e-6 | 1.5e-5 | |
| KEGG_PATHWAY | hsa05134:Legionellosis | 21 | 1.9 | 9.8e-6 | 2.2e-5 | |
| KEGG_PATHWAY | hsa04512:ECM-receptor interaction | 29 | 2.6 | 1.0e-5 | 2.2e-5 | |
| KEGG_PATHWAY | hsa05032:Morphine addiction | 28 | 2.6 | 1.5e-5 | 3.3e-5 | |
| KEGG_PATHWAY | hsa04726:Serotonergic synapse | 32 | 2.9 | 1.6e-5 | 3.5e-5 | |
| KEGG_PATHWAY | hsa05321:Inflammatory bowel disease (IBD) | 23 | 2.1 | 1.6e-5 | 3.5e-5 | |
| KEGG_PATHWAY | hsa04064:NF-kappa B signaling pathway | 28 | 2.6 | 1.9e-5 | 4.1e-5 | |
| KEGG_PATHWAY | hsa05202:Transcriptional misregulation in cancer | 41 | 3.7 | 3.5e-5 | 7.4e-5 | |
| KEGG_PATHWAY | hsa03013:RNA transport | 40 | 3.7 | 6.9e-5 | 0.00014 | |
| KEGG_PATHWAY | hsa05014:Amyotrophic lateral sclerosis (ALS) | 19 | 1.7 | 7.6e-5 | 0.00016 | |
| KEGG_PATHWAY | hsa05414:Dilated cardiomyopathy | 26 | 2.4 | 0.0001 | 0.00021 | |
| KEGG_PATHWAY | hsa04115:p53 signaling pathway | 22 | 2.0 | 0.00012 | 0.00025 | |
| KEGG_PATHWAY | hsa04530:Tight junction | 35 | 3.2 | 0.00013 | 0.00026 | |
| KEGG_PATHWAY | hsa04350:TGF-beta signaling pathway | 25 | 2.3 | 0.00015 | 0.0003 | |
| KEGG_PATHWAY | hsa04913:Ovarian steroidogenesis | 18 | 1.6 | 0.00015 | 0.0003 | |
| KEGG_PATHWAY | hsa05216:Thyroid cancer | 13 | 1.2 | 0.00018 | 0.00036 | |
| KEGG_PATHWAY | hsa04972:Pancreatic secretion | 25 | 2.3 | 0.00019 | 0.00037 | |
| KEGG_PATHWAY | hsa04320:Dorso-ventral axis formation | 11 | 1.0 | 0.00022 | 0.00043 | |
| KEGG_PATHWAY | hsa04961:Endocrine and other factor-regulated calcium reabsorption | 17 | 1.6 | 0.00022 | 0.00043 | |
| KEGG_PATHWAY | hsa04727:GABAergic synapse | 25 | 2.3 | 0.00028 | 0.00054 | |
| KEGG_PATHWAY | hsa05034:Alcoholism | 35 | 3.2 | 0.00029 | 0.00054 | |
| KEGG_PATHWAY | hsa04360:Axon guidance | 32 | 2.9 | 0.00037 | 0.0007 | |
| KEGG_PATHWAY | hsa05030:Cocaine addiction | 17 | 1.6 | 0.0004 | 0.00074 | |
| KEGG_PATHWAY | hsa04141:Protein processing in endoplasmic reticulum | 38 | 3.5 | 0.00057 | 0.0011 | |
| KEGG_PATHWAY | hsa05020:Prion diseases | 13 | 1.2 | 0.0011 | 0.002 | |
| KEGG_PATHWAY | hsa05010:Alzheimer's disease | 35 | 3.2 | 0.0013 | 0.0024 | |
| KEGG_PATHWAY | hsa05410:Hypertrophic cardiomyopathy (HCM) | 22 | 2.0 | 0.0015 | 0.0028 | |
| KEGG_PATHWAY | hsa05412:Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 20 | 1.8 | 0.0027 | 0.0048 | |
| KEGG_PATHWAY | hsa03040:Spliceosome | 30 | 2.7 | 0.0034 | 0.0061 | |
| KEGG_PATHWAY | hsa05110:Vibrio cholerae infection | 15 | 1.4 | 0.0047 | 0.0082 | |
| KEGG_PATHWAY | hsa05016:Huntington's disease | 36 | 3.3 | 0.0048 | 0.0084 | |
| KEGG_PATHWAY | hsa05144:Malaria | 14 | 1.3 | 0.0084 | 0.015 | |
| KEGG_PATHWAY | hsa04622:RIG-I-like receptor signaling pathway | 18 | 1.6 | 0.011 | 0.018 | |
| KEGG_PATHWAY | hsa05416:Viral myocarditis | 15 | 1.4 | 0.014 | 0.024 | |
| KEGG_PATHWAY | hsa04710:Circadian rhythm | 10 | 0.9 | 0.018 | 0.03 | |
| KEGG_PATHWAY | hsa04060:Cytokine-cytokine receptor interaction | 44 | 4.0 | 0.018 | 0.03 | |
| KEGG_PATHWAY | hsa04070:Phosphatidylinositol signaling system | 21 | 1.9 | 0.019 | 0.032 | |
| KEGG_PATHWAY | hsa04340:Hedgehog signaling pathway | 9 | 0.8 | 0.022 | 0.036 | |
| KEGG_PATHWAY | hsa03430:Mismatch repair | 8 | 0.7 | 0.033 | 0.054 | |
| KEGG_PATHWAY | hsa04330:Notch signaling pathway | 12 | 1.1 | 0.063 | 0.1 | |
| KEGG_PATHWAY | hsa04962:Vasopressin-regulated water reabsorption | 11 | 1.0 | 0.078 | 0.12 | |
| KEGG_PATHWAY | hsa05012:Parkinson's disease | 23 | 2.1 | 0.087 | 0.14 | |
| KEGG_PATHWAY | hsa04973:Carbohydrate digestion and absorption | 10 | 0.9 | 0.097 | 0.15 |